Let's focus on the positive parts though -and it's apropos, considering it's marathon weekends in Boston and London. More than 100 Brooklyn runners in Boston, and I expect to see a fair NYC turnout in the UK.
*When I travel, I run. Mapmyrun or Gmaps Pedometer is a great way of figuring out routes from where you are staying. And on Mapmyrun, you can see what other folk have done in the past.
*Take the unexpected path, even if you don't expect to. When I run in new routes for the first time, I invariably get temporarily lost. Or I have no idea where I'm going. That's the fun of it. Don't be afraid to ask. Again, that's part of the fun. And tacking on an additional 5-15 minutes to your run isn't going to ruin your training - just run slower, or even take walking breaks.
*Find a destination race, and plan a trip around it. MarathonGuide.com is a great place to start.
*Plan a trip, and find a run to fit your needs. For example, I'm up in the Boston area a lot, so use New England Runner and Cool Running to plot out some ideas (these are both great for the Northeast, I might add.)
*Look up a running group online from the area, and send a quick e-mail to see if you can join them on one of their weekly runs. I did this up in the Boston area a few years back since I wanted to go long and I wanted company, and enjoyed a wonderful 16-mile loop on Heartbreak Hill into Wellesley (and back).
Good luck everyone racing this weekend.